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Book Details :
Published on: 1989-12-01
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Original language: English
During the past decade, there have been numerous direct and indirect scientific contributions to both the etiology and therapy of aplastic anemia and related bone marrow failure syndromes. Clinical observations, such as autologous bone marrow recovery after conditioning with immunosup pressive agents for bone marrow transplantation; failure to achieve en graftment in some identical twins without prior immunosuppressive ther apy; and hematologic response to immunosuppressive agents, have led to the concept of immune-mediated etiology of acquired aplastic anemia. Such a concept was further strengthened by laboratory findings, implicat ing the role of activated cytotoxic T lymphocytes and abnormal produc tion of inhibitory lymphokines. The immunologic mechanisms may also apply to the idiosyncratic bone marrow aplasias associated with drugs, toxic chemicals, and viruses. These agents may alter normal cellular recog nition sites by interacting with cellular components and result in loss of self tolerance. Immunologic mechanisms have long been advocated in many other organ failures, and the hemopoietic organ is no exception. It is of interest that parallel clinical and laboratory investigations in juvenile diabetes mellitus type I and in rodent models of this disease have yielded results compatible with the same pathogenic mechanisms. The infiltration of pancreatic islets by activated T lymphocytes, functional and morphological alterations of islet cells upon incubation with lymphokines such as gamma interferon and tumor necrosis factor, and clinical response to cyclosporine are a few examples. Glossary of Terms Aplastic Anemia and MDS International ... The following is a glossary of terms related to bone marrow failure diseases. You can also browse the glossary of drug names. Aplastic and other anemias and other bone marrow failure ... Home 2017 ICD-10-CM Diagnosis Codes Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism D50-D89 Acquired Aplastic Anemia - NORD (National Organization for ... General Discussion Summary Acquired aplastic anemia is a rare serious blood disorder due to failure of the bone marrow failure to produce blood cells. Aplastic anemia definition of aplastic anemia by Medical ... Aplastic Anemia Definition Aplastic anemia is a disorder in which the bone marrow greatly decreases or stops production of blood cells. Description The bone marrow ... The Pathophysiology of Acquired Aplastic Anemia NEJM Hematopoiesis in Bone Marrow Failure. By any measure hematopoiesis is greatly impaired in aplastic anemia. By definition there is pancytopenia and the most ... Aplastic Anemia: Review of Etiology and Treatment Diagnostic Evaluation The hallmark of aplastic anemia is pancytopenia and a hypocellular bone marrow.2 A complete blood count is the initial diagnostic study and ... Telomere Syndromes and Dyskeratosis Congenita: Johns ... Telomere syndromes are inherited conditions that can cause bone marrow failure and lung disease. These syndromes vary in severity and can affect children and adults ... Learning is Hope Aplastic Anemia and MDS International ... The Aplastic Anemia and MDS International Foundation is the world's leading nonprofit health organization dedicated to patients afflicted with bone marrow failure ... Aplastic Anemia Clinical Trials Aplastic Anemia: What is Aplastic Anemia? Aplastic Anemia Symptoms: Aplastic Anemia Diagnosis: Treatment Options Blood Transfusion Medication Bone marrow failure - Wikipedia History. Bone marrow failure is associated with three types of diseases Fanconi anemia (FA) dyskeratosis congenita and aplastic anemia. Fanconi anemia is an ...
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